The possible role of Interleukin-6 as a regulator of insulin sensitivity in patients with neuromyelitis optica spectrum disorder

Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity. Methods We aimed determine the risk association of hyperinsulinemia in NMOSD patients seropositive AQP4-IgG and serum levels interleukin (IL)-6 IL-17A compared control group. Serum metabolic (Insulin, Fasting Blood Sugar (FBS), lipid profile) (IL-6 IL-17) markers were assessed 56 100 controls. Results Hyperinsulinemia was more prevalent independent age, sex body mass index (BMI) (48.2% vs. 26%, p = 0.005) After adjusting BMI, there significant between lower sensitivity (IS) (95% CI: Beta 0.73, 0.62 0.86, 0.0001). Circulating IL-6 IL-17 higher patients, only had an effect modifier for risk. Conclusions Our data suggests pathogenesis leads increases resistance.